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One serious adverse event is propofol-related infusion syndrome or propofol infusion syndrome (PRIS), a constellation of signs and symptoms, including bradycardia, metabolic acidosis, liver enlargement, lipemic plasma, rhabdomyolysis and or myoglobinuria, and even death Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation --- bjaed org article S1743-1816(17)30024-0 pdfZusammenfassung: Das Propofol-Infusions-Syndrom (PRIS) ist eine sehr seltene, gehäuft bei Kindern auftreten-de, unerwünschte Nebenwirkung einer Sedierung mit Propofol --- med unc edu pediatrics cccp PCCM-PICU-Propofol-Guideline-201706 pdffrcaheadstart org downloads ICU pris pdfMechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation cumming ucalgary ca CPT%20Pearl%20Propofol%20Related%20Infusion%20Syndrom The term PRIS—propofol infusion syndrome— was originally coined by Bray in 1998 to de-scribe the adverse effects associated with the use of propofol in the paediatric population Initial definition of PRIS Defined as acute refractory bradycardia leading to asystole in the presence of one or more of the following:The term PRIS—propofol infusion syndrome— was originally coined by Bray in 1998 to de-scribe the adverse effects associated with the use of propofol in the paediatric population Initial definition of PRIS Defined as acute refractory bradycardia leading to asystole in the presence of one or more of the following:Summary: The propofol infusion syndrome (PRIS) is a very rare, undesired adverse effect of sedation with propofol that occurs most frequently in children Despite the fact that a number of fatal cases documented, the syndrome is still rela-tively unknown Both catecholamine and glucocorticoid administration are associated with the development of PRIS It is recommended to discontinue these medications if possible while on propofol infusion or select an alternative sedative if they cannot be discontinued If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS med virginia edu ginutrition wp-content uploads sites 199 MikeArticle pdf--- ai-online info images ai-ausgabe 2004 10-2004 04_10_580-584 pdfIf PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS medical-case-reports imedpub com the-growing-concern-of-propofolrelated-i
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