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--- bjaed org article S1743-1816(17)30024-0 pdfmed virginia edu ginutrition wp-content uploads sites 199 MikeArticle pdfSummary: The propofol infusion syndrome (PRIS) is a very rare, undesired adverse effect of sedation with propofol that occurs most frequently in children Despite the fact that a number of fatal cases documented, the syndrome is still rela-tively unknown --- ai-online info images ai-ausgabe 2004 10-2004 04_10_580-584 pdf--- med unc edu pediatrics cccp PCCM-PICU-Propofol-Guideline-201706 pdfIf PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Initial definition of PRIS Defined as acute refractory bradycardia leading to asystole in the presence of one or more of the following:The term PRIS—propofol infusion syndrome— was originally coined by Bray in 1998 to de-scribe the adverse effects associated with the use of propofol in the paediatric population Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism cumming ucalgary ca CPT%20Pearl%20Propofol%20Related%20Infusion%20Syndrom The term PRIS—propofol infusion syndrome— was originally coined by Bray in 1998 to de-scribe the adverse effects associated with the use of propofol in the paediatric population frcaheadstart org downloads ICU pris pdfInitial definition of PRIS Defined as acute refractory bradycardia leading to asystole in the presence of one or more of the following:Both catecholamine and glucocorticoid administration are associated with the development of PRIS It is recommended to discontinue these medications if possible while on propofol infusion or select an alternative sedative if they cannot be discontinued Zusammenfassung: Das Propofol-Infusions-Syndrom (PRIS) ist eine sehr seltene, gehäuft bei Kindern auftreten-de, unerwünschte Nebenwirkung einer Sedierung mit Propofol One serious adverse event is propofol-related infusion syndrome or propofol infusion syndrome (PRIS), a constellation of signs and symptoms, including bradycardia, metabolic acidosis, liver enlargement, lipemic plasma, rhabdomyolysis and or myoglobinuria, and even death PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation medical-case-reports imedpub com the-growing-concern-of-propofolrelated-i If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS PRIS is an uncommon but serious complication that usually arises in patients undergoing prolonged propofol infusions, especially those receiving higher doses The precise mechanisms behind PRIS are intricate and remain under active investigation
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